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Background: There are few reports describing chromosomal abnormalities in transsexuals. In rare cases, transsexualism and sexual chromosomal multiplicity coexist.

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Six cases of male-to-female transsexuals with 47,XYY chromosomal pattern have been ly reported. We have not encountered any female transsexual cases with 47,XXX karyotype in the literature. Methods: A year-old female patient came to our outpatient department with depressive symptoms and suicidal thoughts.

On psychiatric interview, she reported that she had feelings of discomfort with her gender identity and had desired to be male since her childhood. Then, we performed cytogenetic investigation using blood culture and G chromosome banding. Conclusions: We conclude that sexual chromosomal abnormalities in some transsexuals may cause a vulnerability to development of a gender identity disorder.

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Abstract Background: There are few reports describing chromosomal abnormalities in transsexuals. Similar articles Two transsexuals with XYY karyotype. Buhrich N, et al. Br J Psychiatry.

PMID: A transsexual male with 47,XYY karyotype. Taneja N, et al. Karyotyping, is it worthwhile in transsexualism? Inoubli A, et al.

Female-to-male transsexual with 47,xxx karyotype

J Sex Med. Epub Nov The transsexual brain--A review of findings on the neural basis of transsexualism. Smith ES, et al. Neurosci Biobehav Rev. Epub Sep PMID: Review. Cognitive correlates of biologic sex and gender identity in transsexualism. Hunt DD, et al. Arch Sex Behav. See all similar articles.

Publication types Case Reports Actions. MeSH terms Adult Actions. Female Actions. Genetic Predisposition to Disease Actions.

Humans Actions. Intelligence Actions. Karyotyping Actions. Related information MedGen. Full text links [x] Elsevier Science. Copy Download.